diff --git a/src/citra_qt/bootmanager.cpp b/src/citra_qt/bootmanager.cpp
index 39115f31e..ef47dcf9c 100644
--- a/src/citra_qt/bootmanager.cpp
+++ b/src/citra_qt/bootmanager.cpp
@@ -15,6 +15,7 @@
 #include "input_common/main.h"
 #include "input_common/motion_emu.h"
 #include "network/network.h"
+#include "video_core/video_core.h"
 
 EmuThread::EmuThread(GRenderWindow* render_window) : render_window(render_window) {}
 
@@ -335,6 +336,19 @@ void GRenderWindow::InitRenderTarget() {
     BackupGeometry();
 }
 
+void GRenderWindow::CaptureScreenshot(u16 res_scale, const QString& screenshot_path) {
+    if (!res_scale)
+        res_scale = VideoCore::GetResolutionScaleFactor();
+    const Layout::FramebufferLayout layout{Layout::FrameLayoutFromResolutionScale(res_scale)};
+    screenshot_image = QImage(QSize(layout.width, layout.height), QImage::Format_RGB32);
+    VideoCore::RequestScreenshot(screenshot_image.bits(),
+                                 [=] {
+                                     screenshot_image.mirrored(false, true).save(screenshot_path);
+                                     LOG_INFO(Frontend, "The screenshot is saved.");
+                                 },
+                                 layout);
+}
+
 void GRenderWindow::OnMinimalClientAreaChangeRequest(
     const std::pair<unsigned, unsigned>& minimal_size) {
     setMinimumSize(minimal_size.first, minimal_size.second);
diff --git a/src/citra_qt/bootmanager.h b/src/citra_qt/bootmanager.h
index 56b00ea70..567fe19f1 100644
--- a/src/citra_qt/bootmanager.h
+++ b/src/citra_qt/bootmanager.h
@@ -8,6 +8,7 @@
 #include <condition_variable>
 #include <mutex>
 #include <QGLWidget>
+#include <QImage>
 #include <QThread>
 #include "common/thread.h"
 #include "core/core.h"
@@ -139,6 +140,8 @@ public:
 
     void InitRenderTarget();
 
+    void CaptureScreenshot(u16 res_scale, const QString& screenshot_path);
+
 public slots:
     void moveContext(); // overridden
 
@@ -165,6 +168,9 @@ private:
 
     EmuThread* emu_thread;
 
+    /// Temporary storage of the screenshot taken
+    QImage screenshot_image;
+
 protected:
     void showEvent(QShowEvent* event) override;
 };
diff --git a/src/citra_qt/configuration/config.cpp b/src/citra_qt/configuration/config.cpp
index 3004fa936..d696ed98d 100644
--- a/src/citra_qt/configuration/config.cpp
+++ b/src/citra_qt/configuration/config.cpp
@@ -206,6 +206,8 @@ void Config::ReadValues() {
     UISettings::values.theme = ReadSetting("theme", UISettings::themes[0].second).toString();
     UISettings::values.enable_discord_presence =
         ReadSetting("enable_discord_presence", true).toBool();
+    UISettings::values.screenshot_resolution_factor =
+        static_cast<u16>(ReadSetting("screenshot_resolution_factor", 0).toUInt());
 
     qt_config->beginGroup("Updater");
     UISettings::values.check_for_update_on_start =
@@ -251,6 +253,7 @@ void Config::ReadValues() {
     UISettings::values.symbols_path = ReadSetting("symbolsPath").toString();
     UISettings::values.movie_record_path = ReadSetting("movieRecordPath").toString();
     UISettings::values.movie_playback_path = ReadSetting("moviePlaybackPath").toString();
+    UISettings::values.screenshot_path = ReadSetting("screenshotPath").toString();
     UISettings::values.game_dir_deprecated = ReadSetting("gameListRootDir", ".").toString();
     UISettings::values.game_dir_deprecated_deepscan =
         ReadSetting("gameListDeepScan", false).toBool();
@@ -460,6 +463,8 @@ void Config::SaveValues() {
     qt_config->beginGroup("UI");
     WriteSetting("theme", UISettings::values.theme, UISettings::themes[0].second);
     WriteSetting("enable_discord_presence", UISettings::values.enable_discord_presence, true);
+    WriteSetting("screenshot_resolution_factor", UISettings::values.screenshot_resolution_factor,
+                 0);
 
     qt_config->beginGroup("Updater");
     WriteSetting("check_for_update_on_start", UISettings::values.check_for_update_on_start, true);
@@ -487,6 +492,7 @@ void Config::SaveValues() {
     WriteSetting("symbolsPath", UISettings::values.symbols_path);
     WriteSetting("movieRecordPath", UISettings::values.movie_record_path);
     WriteSetting("moviePlaybackPath", UISettings::values.movie_playback_path);
+    WriteSetting("screenshotPath", UISettings::values.screenshot_path);
     qt_config->beginWriteArray("gamedirs");
     for (int i = 0; i < UISettings::values.game_dirs.size(); ++i) {
         qt_config->setArrayIndex(i);
diff --git a/src/citra_qt/main.cpp b/src/citra_qt/main.cpp
index db6ba6202..341c11dc3 100644
--- a/src/citra_qt/main.cpp
+++ b/src/citra_qt/main.cpp
@@ -365,6 +365,7 @@ void GMainWindow::InitializeHotkeys() {
                                    Qt::ApplicationShortcut);
     hotkey_registry.RegisterHotkey("Main Window", "Remove Amiibo", QKeySequence(Qt::Key_F3),
                                    Qt::ApplicationShortcut);
+    hotkey_registry.RegisterHotkey("Main Window", "Capture Screenshot", QKeySequence(tr("CTRL+P")));
 
     hotkey_registry.LoadHotkeys();
 
@@ -439,6 +440,12 @@ void GMainWindow::InitializeHotkeys() {
                     OnRemoveAmiibo();
                 }
             });
+    connect(hotkey_registry.GetHotkey("Main Window", "Capture Screenshot", this),
+            &QShortcut::activated, this, [&] {
+                if (emu_thread->IsRunning()) {
+                    OnCaptureScreenshot();
+                }
+            });
 }
 
 void GMainWindow::ShowUpdaterWidgets() {
@@ -588,6 +595,8 @@ void GMainWindow::ConnectMenuEvents() {
             Core::System::GetInstance().frame_limiter.AdvanceFrame();
         }
     });
+    connect(ui.action_Capture_Screenshot, &QAction::triggered, this,
+            &GMainWindow::OnCaptureScreenshot);
 
     // Help
     connect(ui.action_Open_Citra_Folder, &QAction::triggered, this,
@@ -882,6 +891,7 @@ void GMainWindow::ShutdownGame() {
     ui.action_Enable_Frame_Advancing->setEnabled(false);
     ui.action_Enable_Frame_Advancing->setChecked(false);
     ui.action_Advance_Frame->setEnabled(false);
+    ui.action_Capture_Screenshot->setEnabled(false);
     render_window->hide();
     if (game_list->isEmpty())
         game_list_placeholder->show();
@@ -1169,6 +1179,7 @@ void GMainWindow::OnStartGame() {
     ui.action_Load_Amiibo->setEnabled(true);
     ui.action_Report_Compatibility->setEnabled(true);
     ui.action_Enable_Frame_Advancing->setEnabled(true);
+    ui.action_Capture_Screenshot->setEnabled(true);
 
     discord_rpc->Update();
 }
@@ -1179,6 +1190,7 @@ void GMainWindow::OnPauseGame() {
     ui.action_Start->setEnabled(true);
     ui.action_Pause->setEnabled(false);
     ui.action_Stop->setEnabled(true);
+    ui.action_Capture_Screenshot->setEnabled(false);
 }
 
 void GMainWindow::OnStopGame() {
@@ -1539,6 +1551,18 @@ void GMainWindow::OnStopRecordingPlayback() {
     ui.action_Stop_Recording_Playback->setEnabled(false);
 }
 
+void GMainWindow::OnCaptureScreenshot() {
+    OnPauseGame();
+    const QString path =
+        QFileDialog::getSaveFileName(this, tr("Capture Screenshot"),
+                                     UISettings::values.screenshot_path, tr("PNG Image (*.png)"));
+    if (!path.isEmpty()) {
+        UISettings::values.screenshot_path = QFileInfo(path).path();
+        render_window->CaptureScreenshot(UISettings::values.screenshot_resolution_factor, path);
+    }
+    OnStartGame();
+}
+
 void GMainWindow::UpdateStatusBar() {
     if (emu_thread == nullptr) {
         status_bar_update_timer.stop();
diff --git a/src/citra_qt/main.h b/src/citra_qt/main.h
index 84ee2cbf7..0d561508a 100644
--- a/src/citra_qt/main.h
+++ b/src/citra_qt/main.h
@@ -183,6 +183,7 @@ private slots:
     void OnRecordMovie();
     void OnPlayMovie();
     void OnStopRecordingPlayback();
+    void OnCaptureScreenshot();
     void OnCoreError(Core::System::ResultStatus, std::string);
     /// Called whenever a user selects Help->About Citra
     void OnMenuAboutCitra();
diff --git a/src/citra_qt/main.ui b/src/citra_qt/main.ui
index a3d66ba11..8bcc9cce3 100644
--- a/src/citra_qt/main.ui
+++ b/src/citra_qt/main.ui
@@ -131,6 +131,8 @@
     <addaction name="separator"/>
     <addaction name="action_Enable_Frame_Advancing"/>
     <addaction name="action_Advance_Frame"/>
+    <addaction name="separator"/>
+    <addaction name="action_Capture_Screenshot"/>
    </widget>
    <widget class="QMenu" name="menu_Multiplayer">
     <property name="enabled">
@@ -315,6 +317,14 @@
     <string>Advance Frame</string>
    </property>
   </action>
+  <action name="action_Capture_Screenshot">
+   <property name="enabled">
+    <bool>false</bool>
+   </property>
+   <property name="text">
+    <string>Capture Screenshot</string>
+   </property>
+  </action>
   <action name="action_View_Lobby">
    <property name="enabled">
     <bool>true</bool>
diff --git a/src/citra_qt/ui_settings.h b/src/citra_qt/ui_settings.h
index caa6a353f..1e09dd7e8 100644
--- a/src/citra_qt/ui_settings.h
+++ b/src/citra_qt/ui_settings.h
@@ -10,6 +10,7 @@
 #include <QMetaType>
 #include <QString>
 #include <QStringList>
+#include "common/common_types.h"
 
 namespace UISettings {
 
@@ -78,10 +79,13 @@ struct Values {
     GameListText game_list_row_2;
     bool game_list_hide_no_icon;
 
+    u16 screenshot_resolution_factor;
+
     QString roms_path;
     QString symbols_path;
     QString movie_record_path;
     QString movie_playback_path;
+    QString screenshot_path;
     QString game_dir_deprecated;
     bool game_dir_deprecated_deepscan;
     QList<UISettings::GameDir> game_dirs;
diff --git a/src/core/frontend/framebuffer_layout.cpp b/src/core/frontend/framebuffer_layout.cpp
index b49d7f509..8456e1300 100644
--- a/src/core/frontend/framebuffer_layout.cpp
+++ b/src/core/frontend/framebuffer_layout.cpp
@@ -191,4 +191,50 @@ FramebufferLayout CustomFrameLayout(unsigned width, unsigned height) {
     res.bottom_screen = bot_screen;
     return res;
 }
+
+FramebufferLayout FrameLayoutFromResolutionScale(u16 res_scale) {
+    FramebufferLayout layout;
+    if (Settings::values.custom_layout == true) {
+        layout = CustomFrameLayout(
+            std::max(Settings::values.custom_top_right, Settings::values.custom_bottom_right),
+            std::max(Settings::values.custom_top_bottom, Settings::values.custom_bottom_bottom));
+    } else {
+        int width, height;
+        switch (Settings::values.layout_option) {
+        case Settings::LayoutOption::SingleScreen:
+            if (Settings::values.swap_screen) {
+                width = Core::kScreenBottomWidth * res_scale;
+                height = Core::kScreenBottomHeight * res_scale;
+            } else {
+                width = Core::kScreenTopWidth * res_scale;
+                height = Core::kScreenTopHeight * res_scale;
+            }
+            layout = SingleFrameLayout(width, height, Settings::values.swap_screen);
+            break;
+        case Settings::LayoutOption::LargeScreen:
+            if (Settings::values.swap_screen) {
+                width = (Core::kScreenBottomWidth + Core::kScreenTopWidth / 4) * res_scale;
+                height = Core::kScreenBottomHeight * res_scale;
+            } else {
+                width = (Core::kScreenTopWidth + Core::kScreenBottomWidth / 4) * res_scale;
+                height = Core::kScreenTopHeight * res_scale;
+            }
+            layout = LargeFrameLayout(width, height, Settings::values.swap_screen);
+            break;
+        case Settings::LayoutOption::SideScreen:
+            width = (Core::kScreenTopWidth + Core::kScreenBottomWidth) * res_scale;
+            height = Core::kScreenTopHeight * res_scale;
+            layout = SideFrameLayout(width, height, Settings::values.swap_screen);
+            break;
+        case Settings::LayoutOption::Default:
+        default:
+            width = Core::kScreenTopWidth * res_scale;
+            height = (Core::kScreenTopHeight + Core::kScreenBottomHeight) * res_scale;
+            layout = DefaultFrameLayout(width, height, Settings::values.swap_screen);
+            break;
+        }
+    }
+    return layout;
+}
+
 } // namespace Layout
diff --git a/src/core/frontend/framebuffer_layout.h b/src/core/frontend/framebuffer_layout.h
index b40bf94b6..3eb9d468c 100644
--- a/src/core/frontend/framebuffer_layout.h
+++ b/src/core/frontend/framebuffer_layout.h
@@ -72,4 +72,11 @@ FramebufferLayout SideFrameLayout(unsigned width, unsigned height, bool is_swapp
  */
 FramebufferLayout CustomFrameLayout(unsigned width, unsigned height);
 
+/**
+ * Convenience method to get frame layout by resolution scale
+ * Read from the current settings to determine which layout to use.
+ * @param res_scale resolution scale factor
+ */
+FramebufferLayout FrameLayoutFromResolutionScale(u16 res_scale);
+
 } // namespace Layout
diff --git a/src/video_core/renderer_opengl/gl_rasterizer_cache.cpp b/src/video_core/renderer_opengl/gl_rasterizer_cache.cpp
index 2a377e543..638096e34 100644
--- a/src/video_core/renderer_opengl/gl_rasterizer_cache.cpp
+++ b/src/video_core/renderer_opengl/gl_rasterizer_cache.cpp
@@ -24,7 +24,6 @@
 #include "common/vector_math.h"
 #include "core/frontend/emu_window.h"
 #include "core/memory.h"
-#include "core/settings.h"
 #include "video_core/pica_state.h"
 #include "video_core/renderer_base.h"
 #include "video_core/renderer_opengl/gl_rasterizer_cache.h"
@@ -78,12 +77,6 @@ constexpr auto RangeFromInterval(Map& map, const Interval& interval) {
     return boost::make_iterator_range(map.equal_range(interval));
 }
 
-static u16 GetResolutionScaleFactor() {
-    return !Settings::values.resolution_factor
-               ? VideoCore::g_renderer->GetRenderWindow().GetFramebufferLayout().GetScalingRatio()
-               : Settings::values.resolution_factor;
-}
-
 template <bool morton_to_gl, PixelFormat format>
 static void MortonCopyTile(u32 stride, u8* tile_buffer, u8* gl_buffer) {
     constexpr u32 bytes_per_pixel = SurfaceParams::GetFormatBpp(format) / 8;
@@ -1360,9 +1353,9 @@ SurfaceSurfaceRect_Tuple RasterizerCacheOpenGL::GetFramebufferSurfaces(
     const auto& config = regs.framebuffer.framebuffer;
 
     // update resolution_scale_factor and reset cache if changed
-    static u16 resolution_scale_factor = GetResolutionScaleFactor();
-    if (resolution_scale_factor != GetResolutionScaleFactor()) {
-        resolution_scale_factor = GetResolutionScaleFactor();
+    static u16 resolution_scale_factor = VideoCore::GetResolutionScaleFactor();
+    if (resolution_scale_factor != VideoCore::GetResolutionScaleFactor()) {
+        resolution_scale_factor = VideoCore::GetResolutionScaleFactor();
         FlushAll();
         while (!surface_cache.empty())
             UnregisterSurface(*surface_cache.begin()->second.begin());
diff --git a/src/video_core/renderer_opengl/renderer_opengl.cpp b/src/video_core/renderer_opengl/renderer_opengl.cpp
index ee6e4045c..e5c4e290a 100644
--- a/src/video_core/renderer_opengl/renderer_opengl.cpp
+++ b/src/video_core/renderer_opengl/renderer_opengl.cpp
@@ -140,7 +140,39 @@ void RendererOpenGL::SwapBuffers() {
         }
     }
 
-    DrawScreens();
+    if (VideoCore::g_renderer_screenshot_requested) {
+        // Draw this frame to the screenshot framebuffer
+        screenshot_framebuffer.Create();
+        GLuint old_read_fb = state.draw.read_framebuffer;
+        GLuint old_draw_fb = state.draw.draw_framebuffer;
+        state.draw.read_framebuffer = state.draw.draw_framebuffer = screenshot_framebuffer.handle;
+        state.Apply();
+
+        Layout::FramebufferLayout layout{VideoCore::g_screenshot_framebuffer_layout};
+
+        GLuint renderbuffer;
+        glGenRenderbuffers(1, &renderbuffer);
+        glBindRenderbuffer(GL_RENDERBUFFER, renderbuffer);
+        glRenderbufferStorage(GL_RENDERBUFFER, GL_RGB8, layout.width, layout.height);
+        glFramebufferRenderbuffer(GL_FRAMEBUFFER, GL_COLOR_ATTACHMENT0, GL_RENDERBUFFER,
+                                  renderbuffer);
+
+        DrawScreens(layout);
+
+        glReadPixels(0, 0, layout.width, layout.height, GL_BGRA, GL_UNSIGNED_INT_8_8_8_8_REV,
+                     VideoCore::g_screenshot_bits);
+
+        screenshot_framebuffer.Release();
+        state.draw.read_framebuffer = old_read_fb;
+        state.draw.draw_framebuffer = old_draw_fb;
+        state.Apply();
+        glDeleteRenderbuffers(1, &renderbuffer);
+
+        VideoCore::g_screenshot_complete_callback();
+        VideoCore::g_renderer_screenshot_requested = false;
+    }
+
+    DrawScreens(render_window.GetFramebufferLayout());
 
     Core::System::GetInstance().perf_stats.EndSystemFrame();
 
@@ -386,14 +418,13 @@ void RendererOpenGL::DrawSingleScreenRotated(const ScreenInfo& screen_info, floa
 /**
  * Draws the emulated screens to the emulator window.
  */
-void RendererOpenGL::DrawScreens() {
+void RendererOpenGL::DrawScreens(const Layout::FramebufferLayout& layout) {
     if (VideoCore::g_renderer_bg_color_update_requested.exchange(false)) {
         // Update background color before drawing
         glClearColor(Settings::values.bg_red, Settings::values.bg_green, Settings::values.bg_blue,
                      0.0f);
     }
 
-    auto layout = render_window.GetFramebufferLayout();
     const auto& top_screen = layout.top_screen;
     const auto& bottom_screen = layout.bottom_screen;
 
diff --git a/src/video_core/renderer_opengl/renderer_opengl.h b/src/video_core/renderer_opengl/renderer_opengl.h
index 87b45529b..4dfc40968 100644
--- a/src/video_core/renderer_opengl/renderer_opengl.h
+++ b/src/video_core/renderer_opengl/renderer_opengl.h
@@ -13,6 +13,10 @@
 #include "video_core/renderer_opengl/gl_resource_manager.h"
 #include "video_core/renderer_opengl/gl_state.h"
 
+namespace Layout {
+class FramebufferLayout;
+}
+
 namespace OpenGL {
 
 /// Structure used for storing information about the textures for each 3DS screen
@@ -50,7 +54,7 @@ private:
     void InitOpenGLObjects();
     void ConfigureFramebufferTexture(TextureInfo& texture,
                                      const GPU::Regs::FramebufferConfig& framebuffer);
-    void DrawScreens();
+    void DrawScreens(const Layout::FramebufferLayout& layout);
     void DrawSingleScreenRotated(const ScreenInfo& screen_info, float x, float y, float w, float h);
     void UpdateFramerate();
 
@@ -66,6 +70,7 @@ private:
     OGLVertexArray vertex_array;
     OGLBuffer vertex_buffer;
     OGLProgram shader;
+    OGLFramebuffer screenshot_framebuffer;
 
     /// Display information for top and bottom screens respectively
     std::array<ScreenInfo, 3> screen_infos;
diff --git a/src/video_core/video_core.cpp b/src/video_core/video_core.cpp
index f8b636de4..e9bc65f6e 100644
--- a/src/video_core/video_core.cpp
+++ b/src/video_core/video_core.cpp
@@ -4,6 +4,7 @@
 
 #include <memory>
 #include "common/logging/log.h"
+#include "core/settings.h"
 #include "video_core/pica.h"
 #include "video_core/renderer_base.h"
 #include "video_core/renderer_opengl/renderer_opengl.h"
@@ -22,6 +23,11 @@ std::atomic<bool> g_hw_shader_enabled;
 std::atomic<bool> g_hw_shader_accurate_gs;
 std::atomic<bool> g_hw_shader_accurate_mul;
 std::atomic<bool> g_renderer_bg_color_update_requested;
+// Screenshot
+std::atomic<bool> g_renderer_screenshot_requested;
+void* g_screenshot_bits;
+std::function<void()> g_screenshot_complete_callback;
+Layout::FramebufferLayout g_screenshot_framebuffer_layout;
 
 /// Initialize the video core
 Core::System::ResultStatus Init(EmuWindow& emu_window) {
@@ -48,4 +54,27 @@ void Shutdown() {
     LOG_DEBUG(Render, "shutdown OK");
 }
 
+void RequestScreenshot(void* data, std::function<void()> callback,
+                       const Layout::FramebufferLayout& layout) {
+    if (g_renderer_screenshot_requested) {
+        LOG_ERROR(Render, "A screenshot is already requested or in progress, ignoring the request");
+        return;
+    }
+    g_screenshot_bits = data;
+    g_screenshot_complete_callback = std::move(callback);
+    g_screenshot_framebuffer_layout = layout;
+    g_renderer_screenshot_requested = true;
+}
+
+u16 GetResolutionScaleFactor() {
+    if (g_hw_renderer_enabled) {
+        return !Settings::values.resolution_factor
+                   ? g_renderer->GetRenderWindow().GetFramebufferLayout().GetScalingRatio()
+                   : Settings::values.resolution_factor;
+    } else {
+        // Software renderer always render at native resolution
+        return 1;
+    }
+}
+
 } // namespace VideoCore
diff --git a/src/video_core/video_core.h b/src/video_core/video_core.h
index deee7a7a7..0c582f1fc 100644
--- a/src/video_core/video_core.h
+++ b/src/video_core/video_core.h
@@ -7,6 +7,7 @@
 #include <atomic>
 #include <memory>
 #include "core/core.h"
+#include "core/frontend/emu_window.h"
 
 class EmuWindow;
 class RendererBase;
@@ -26,6 +27,11 @@ extern std::atomic<bool> g_hw_shader_enabled;
 extern std::atomic<bool> g_hw_shader_accurate_gs;
 extern std::atomic<bool> g_hw_shader_accurate_mul;
 extern std::atomic<bool> g_renderer_bg_color_update_requested;
+// Screenshot
+extern std::atomic<bool> g_renderer_screenshot_requested;
+extern void* g_screenshot_bits;
+extern std::function<void()> g_screenshot_complete_callback;
+extern Layout::FramebufferLayout g_screenshot_framebuffer_layout;
 
 /// Initialize the video core
 Core::System::ResultStatus Init(EmuWindow& emu_window);
@@ -33,4 +39,10 @@ Core::System::ResultStatus Init(EmuWindow& emu_window);
 /// Shutdown the video core
 void Shutdown();
 
+/// Request a screenshot of the next frame
+void RequestScreenshot(void* data, std::function<void()> callback,
+                       const Layout::FramebufferLayout& layout);
+
+u16 GetResolutionScaleFactor();
+
 } // namespace VideoCore